Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products.

نویسندگان

  • A C Garapin
  • L Fanshier
  • J A Leong
  • J Jackson
  • W Levinson
  • J M Bishop
چکیده

The deoxyribonucleic acid (DNA) polymerase(s) of Rous sarcoma virus synthesizes two principal products-single-stranded DNA in the form of a DNA:ribonucleic acid (RNA) hybrid and double-stranded DNA. All of the single-stranded product and 50% of the double-stranded product can be hybridized to 70S viral RNA. These results, in combination with data obtained by analysis of the kinetics of double-stranded DNA synthesis, indicate that the synthesis of double-stranded DNA is a sequel to the synthesis of single-stranded DNA and is dependent upon the latter for the provision of initial template.

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عنوان ژورنال:
  • Journal of virology

دوره 7 2  شماره 

صفحات  -

تاریخ انتشار 1971